Common variable immunodeficiency, unspecified

This code represents a primary immunodeficiency disorder characterized by impaired antibody production, leading to recurrent infections. Patients typically present with low levels of immunoglobulin G (IgG), IgA, and/or IgM, and poor vaccine responses. The "unspecified" nature indicates that the specific genetic defect or underlying cause of the common variable immunodeficiency (CVID) has not been identified or documented.

Use this code when the physician's documentation confirms a diagnosis of CVID, but the specific type or underlying genetic cause is not further specified. This often occurs when initial diagnostic workup has confirmed the immunodeficiency, but further genetic testing or subtyping is pending or not performed. Documentation should clearly state "common variable immunodeficiency, unspecified" or similar.

• Do not use this code if a more specific type of CVID (e.g., with autoimmune complications, with granulomatous disease) is documented.
• Ensure documentation supports the diagnosis of CVID, including laboratory findings of hypogammaglobulinemia and recurrent infections.
• Consider sequencing this code as a primary diagnosis when it is the main reason for the encounter, especially for management of the immunodeficiency.