Resistance to antifungal drug(s)

This code indicates that a fungal infection is not responding to treatment with one or more antifungal medications. It signifies that the pathogen has developed mechanisms to overcome the effects of previously effective antifungal agents, leading to persistent or recurrent infection.

Use this code when laboratory testing (e.g., antifungal susceptibility testing) confirms resistance to specific antifungal drugs, or when clinical evidence strongly suggests treatment failure despite appropriate antifungal therapy. This applies to various fungal infections, such as candidiasis, aspergillosis, or cryptococcosis, where resistance is identified.

• Always sequence this code after the code for the underlying fungal infection.
• Ensure documentation clearly supports the resistance, ideally with laboratory confirmation or a physician's explicit statement of resistance.
• Do not use this code for treatment failure due to non-compliance or incorrect drug administration; it specifically denotes biological resistance.