Z16.21
ICD-10-CMThis code indicates that a patient's infection is caused by a bacterial strain that is no longer susceptible to vancomycin, a powerful antibiotic often used for serious Gram-positive bacterial infections. This resistance means that vancomycin will not be effective in treating the infection.
Use this code when laboratory testing (e.g., culture and sensitivity) confirms that the causative organism exhibits resistance to vancomycin. This applies to various infections, such as MRSA or enterococcal infections, where vancomycin was considered a potential treatment but is now ineffective due to resistance.
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