Wild-type transthyretin-related (ATTR) amyloidosis

This code identifies a systemic disorder characterized by the extracellular deposition of amyloid fibrils formed from misfolded wild-type transthyretin protein. This accumulation primarily affects the heart, nerves, and gastrointestinal tract, leading to progressive organ dysfunction. It is a non-hereditary form of transthyretin amyloidosis, typically manifesting in older adults.

Use this code for patients diagnosed with wild-type ATTR amyloidosis, often presenting with symptoms like cardiomyopathy (e.g., heart failure with preserved ejection fraction), carpal tunnel syndrome, or spinal stenosis. Documentation should explicitly state "wild-type" or "senile" ATTR amyloidosis, distinguishing it from hereditary forms.

• Differentiate carefully from hereditary ATTR amyloidosis (E85.81) which requires genetic confirmation.
• Ensure documentation specifies "wild-type" to avoid confusion with other amyloidosis types.
• Code any associated manifestations, such as heart failure (I50.x) or carpal tunnel syndrome (G56.0-), as secondary diagnoses.