Acute myeloid leukemia with 11q23-abnormality in relapse

This diagnosis code signifies a specific subtype of acute myeloid leukemia (AML) characterized by a chromosomal abnormality involving the 11q23 region, which has recurred after a period of remission. This genetic alteration is often associated with a less favorable prognosis and can influence treatment strategies.

This code is appropriate for patients diagnosed with AML who have documented evidence of the 11q23 chromosomal abnormality and are experiencing a relapse of their disease. Documentation should clearly state the diagnosis of AML, the presence of the 11q23 abnormality (e.g., KMT2A rearrangement), and that the disease is in a relapsed state.

• Ensure documentation explicitly states "relapse" or "recurrent" disease, not just "persistent" or "refractory."
• Verify the presence of the 11q23 abnormality through cytogenetic or molecular testing reports.
• Do not confuse with AML in remission or AML with other chromosomal abnormalities.