Acute myeloblastic leukemia, in relapse

This code signifies a recurrence of acute myeloblastic leukemia (AML) after a period of remission. AML is a rapidly progressing cancer of the blood and bone marrow, characterized by the overproduction of immature white blood cells (myeloblasts). "In relapse" indicates the disease has returned following prior treatment.

Use this code when documentation explicitly states a patient with a history of AML is now experiencing a relapse of the disease. This typically follows a period of complete remission and is supported by bone marrow biopsy results showing increased myeloblasts, peripheral blood findings, and clinical signs of disease recurrence.

• Distinguish carefully between initial diagnosis, remission, and relapse; documentation must clearly state "in relapse."
• Do not use this code for initial diagnoses of AML or for AML that is refractory to treatment (i.e., never achieved remission).
• Always sequence this code as the primary diagnosis when it is the reason for the encounter.