Atyp chronic myeloid leuk, BCR/ABL-neg, not achieve remis

This code signifies a rare and aggressive form of chronic myeloid leukemia (CML) that lacks the characteristic Philadelphia chromosome (BCR/ABL fusion gene). It is diagnosed when the patient has not yet achieved remission, indicating active disease. This atypical variant presents with features overlapping CML and myelodysplastic/myeloproliferative neoplasms.

Use this code for patients diagnosed with atypical CML who test negative for the BCR/ABL fusion gene and whose medical record clearly indicates ongoing disease activity without remission. Documentation must specify "atypical CML," "BCR/ABL-negative," and the lack of remission status.

• Always confirm the BCR/ABL status; if positive, a different CML code is appropriate.
• Ensure documentation explicitly states "not having achieved remission" to support this specific subcategory.
• Do not confuse with other myeloproliferative neoplasms; atypical CML has distinct diagnostic criteria.