Lymphocyte depleted Hodgkin lymphoma, spleen

This code signifies a diagnosis of lymphocyte-depleted Hodgkin lymphoma, a rare and aggressive subtype of Hodgkin lymphoma, specifically when the disease is localized to the spleen. This form of Hodgkin lymphoma is characterized by a paucity of lymphocytes and an abundance of Reed-Sternberg cells and their variants.

Apply this code when documentation explicitly states a diagnosis of lymphocyte-depleted Hodgkin lymphoma with splenic involvement. This is typically supported by pathology reports confirming the specific subtype and imaging studies or surgical findings indicating primary or metastatic disease in the spleen.

• Ensure the pathology report specifically identifies "lymphocyte-depleted" Hodgkin lymphoma, not just general Hodgkin lymphoma.
• Confirm splenic involvement is documented; do not use this code for other sites of disease.
• Sequence this code as the primary diagnosis when it is the reason for the encounter or treatment.