Lymphocyte depleted Hodgkin lymphoma, unspecified site

This code identifies a specific, rare subtype of Hodgkin lymphoma characterized by a paucity of lymphocytes and an abundance of Reed-Sternberg cells and other reactive cells. It represents a more aggressive form of Hodgkin lymphoma, often presenting with advanced stage disease.

Assign this code when documentation explicitly states a diagnosis of "lymphocyte depleted Hodgkin lymphoma" without specifying a primary anatomical site. This diagnosis is typically confirmed through histopathological examination of a biopsy specimen.

• Ensure the pathology report specifically identifies the "lymphocyte depleted" subtype.
• Do not use this code if a specific anatomical site of involvement is documented; instead, use the more specific C81.3- subcategory codes.
• Always sequence this code as the primary diagnosis when it is the reason for the encounter or treatment.