Mixed cellularity Hodgkin lymphoma, spleen

This code signifies a diagnosis of Hodgkin lymphoma, specifically the mixed cellularity subtype, with documented involvement of the spleen. Mixed cellularity Hodgkin lymphoma is characterized by a heterogeneous cellular infiltrate including Reed-Sternberg cells, lymphocytes, eosinophils, and plasma cells.

Apply this code when pathology reports confirm mixed cellularity Hodgkin lymphoma and imaging or clinical findings indicate splenic involvement. Documentation should clearly state the subtype of Hodgkin lymphoma and the affected anatomical site.

• Ensure the pathology report explicitly states "mixed cellularity" and not another subtype of Hodgkin lymphoma.
• Confirm splenic involvement is documented, not just generalized lymphadenopathy.
• Do not use this code if the splenic involvement is secondary to another primary malignancy; this code is for primary Hodgkin lymphoma.