Mixed cellularity Hodgkin lymphoma, unspecified site

This code identifies a specific subtype of Hodgkin lymphoma characterized by a heterogeneous cellular infiltrate including Reed-Sternberg cells, lymphocytes, eosinophils, and plasma cells. It signifies a diagnosis of mixed cellularity Hodgkin lymphoma where the primary anatomical site of involvement has not been specified in the medical record.

Apply this code when the pathology report confirms mixed cellularity Hodgkin lymphoma, but the physician documentation does not specify a particular lymph node region or extranodal site. This is often used for initial diagnoses before full staging or when the site is generalized and not localized to a single area.

• Avoid using this code if a specific anatomical site (e.g., lymph nodes of head, neck, and trunk) is documented; instead, use a more specific C81.2- subcategory.
• Always sequence this code as the primary diagnosis when it represents the reason for the encounter or admission.
• Ensure the pathology report explicitly states "mixed cellularity" to support this diagnosis.