Activated protein C resistance

This code represents a hereditary or acquired thrombophilia characterized by a poor anticoagulant response to activated protein C (APC). It is a significant risk factor for venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE).

Use this code when documentation confirms a diagnosis of activated protein C resistance, often identified through laboratory testing (e.g., APC resistance assay). This typically occurs in patients presenting with unprovoked or recurrent thrombotic events, or in family members of individuals with known thrombophilia.

• Do not confuse with other hereditary thrombophilias like Factor V Leiden mutation unless APC resistance is explicitly documented.
• Code any associated thrombotic events (e.g., DVT, PE) separately and sequence them according to the encounter's primary reason.
• Ensure documentation specifies "resistance" to activated protein C, not just a deficiency or other protein C-related disorder.