Other anemias due to enzyme disorders

This code signifies anemias resulting from inherited or acquired deficiencies in enzymes other than those specifically classified elsewhere (e.g., G6PD deficiency). These enzyme defects disrupt erythrocyte metabolism, leading to premature destruction of red blood cells and subsequent anemia. Examples include pyruvate kinase deficiency or triosephosphate isomerase deficiency.

Assign this code when documentation specifies an anemia caused by an enzyme disorder not otherwise specified, such as hereditary nonspherocytic hemolytic anemia due to an unlisted enzyme defect. Supporting documentation should include laboratory findings confirming an enzyme deficiency and a diagnosis of anemia linked to this defect.

• Do not use for G6PD deficiency; a more specific code exists for that condition.
• Ensure the documentation clearly links the anemia to an enzyme disorder, not just a general hemolytic anemia.
• Sequence this code as the primary diagnosis when the enzyme disorder is the definitive cause of the anemia.