Anemia due to glucose-6-phosphate dehydrogenase deficiency

This code identifies a specific type of hemolytic anemia resulting from an inherited metabolic disorder where red blood cells lack sufficient glucose-6-phosphate dehydrogenase (G6PD). This enzyme deficiency makes red blood cells vulnerable to oxidative stress, leading to their premature destruction and subsequent anemia.

Apply this code when documentation clearly indicates anemia as a direct consequence of G6PD deficiency. This typically occurs after exposure to oxidative triggers like certain medications, fava beans, or infections in individuals with the genetic predisposition. Supporting documentation should include laboratory findings confirming G6PD deficiency and evidence of hemolytic anemia.

• Do not code this if the patient has G6PD deficiency without any signs or symptoms of anemia; use D75.A instead.
• Ensure the medical record explicitly links the anemia to the G6PD deficiency.
• Consider sequencing this code as the primary diagnosis if the anemia is the chief reason for the encounter.