Anemia due to other disorders of glycolytic enzymes

This code signifies a type of hemolytic anemia resulting from inherited deficiencies in glycolytic enzymes other than pyruvate kinase or glucose-6-phosphate dehydrogenase. These enzyme defects impair the red blood cell's ability to produce energy, leading to premature destruction of erythrocytes. Patients typically present with chronic anemia, jaundice, and splenomegaly.

Assign this code when documentation specifies hemolytic anemia caused by a defect in a glycolytic enzyme, such as phosphofructokinase, hexokinase, or phosphoglycerate kinase, but explicitly excludes pyruvate kinase or G6PD deficiency. Supporting documentation should include laboratory findings confirming the specific enzyme deficiency and evidence of hemolytic anemia.

• Ensure the documentation clearly states "other" glycolytic enzyme deficiency, as specific codes exist for pyruvate kinase (D55.21) and G6PD deficiency (D55.0).
• Do not use this code if the specific enzyme deficiency is unknown or not documented; instead, consider D58.9 (Other specified hemolytic anemias).
• Always sequence this code as the primary diagnosis when it is the reason for the encounter, followed by any associated manifestations or complications.