Acute monoblastic/monocytic leukemia, in relapse

This code signifies a recurrence or worsening of acute monoblastic/monocytic leukemia (AML M5 subtype) after a period of remission. It indicates that the aggressive proliferation of immature monocytes and monoblasts has returned, requiring further treatment.

Apply this code when documentation explicitly states a diagnosis of acute monoblastic/monocytic leukemia that has relapsed. This typically follows a period of complete or partial remission, confirmed by bone marrow biopsy and peripheral blood counts.

• Ensure documentation clearly specifies "in relapse" for acute monoblastic/monocytic leukemia.
• Do not confuse with initial diagnosis or remission status; specific codes exist for those scenarios.
• Always sequence this code as the primary diagnosis when it is the reason for the encounter.