Family history of APOL1-mediated kidney disease [AMKD]

This code indicates a patient has a family history of APOL1-mediated kidney disease (AMKD). AMKD is a spectrum of kidney diseases, including focal segmental glomerulosclerosis (FSGS), hypertension-attributed nephropathy, and HIV-associated nephropathy, linked to genetic variants in the APOL1 gene. This family history suggests an increased genetic predisposition for the patient to develop similar kidney conditions.

Use this code when documentation explicitly states a family history of AMKD, or a specific kidney disease known to be APOL1-mediated, in a first-degree relative. This is often identified during genetic counseling, risk assessment for kidney disease, or when evaluating a patient with early signs of kidney dysfunction and a relevant family history. It is used to indicate a genetic risk factor, not an active disease in the patient.

• Assign this code as a secondary diagnosis when the patient is being seen for screening, genetic counseling, or evaluation of kidney disease where family history is a contributing factor.
• Do not use this code if the patient themselves has a confirmed diagnosis of AMKD; instead, code the specific kidney disease.
• Ensure the documentation clearly specifies "family history" and links it to APOL1-mediated kidney disease or a condition known to be AMKD.