Hormone resistant malignancy status

This code indicates that a patient's malignant neoplasm has developed resistance to hormonal therapy, meaning the cancer no longer responds to treatments designed to block or remove hormones that fuel its growth. This status signifies a more aggressive or advanced stage of the disease, often requiring a change in treatment strategy.

Apply this code when documentation explicitly states that a previously hormone-sensitive malignancy, such as prostate or breast cancer, has become resistant to ongoing or prior hormonal therapy. This is typically used in conjunction with the primary malignancy code to provide a more complete picture of the patient's cancer status and treatment challenges.

• Always sequence this code secondary to the primary malignancy code.
• Ensure documentation clearly specifies "hormone resistant" or "hormone refractory" for the specific cancer type.
• Do not use for cancers that are inherently not hormone-sensitive or for initial diagnosis before hormonal therapy has been attempted and failed.