Anal high risk human papillomavirus (HPV) DNA test positive

This code indicates a positive laboratory finding for high-risk human papillomavirus (HPV) DNA detected from an anal specimen. It signifies the presence of HPV genotypes known to be associated with an increased risk of anal dysplasia and anal cancer. This is a diagnostic finding, not a diagnosis of disease.

Use this code when documentation confirms a positive result from an anal high-risk HPV DNA test. This typically occurs during screening for anal cancer in high-risk populations, such as HIV-positive individuals or men who have sex with men (MSM). The test result must be explicitly stated as positive for high-risk HPV DNA from an anal source.

• Do not code this with A63.0 (anogenital warts/condyloma acuminatum) as per the Excludes1 note; these are distinct clinical entities.
• This code represents a laboratory finding; if a definitive diagnosis of anal dysplasia or cancer is made, code that diagnosis instead or in addition, depending on the specific clinical scenario and sequencing rules.
• Ensure the documentation specifies "high-risk" HPV and the "anal" source of the specimen to accurately assign this code.