Atyp squam cell of undet signfc cyto smr anus (ASC-US)

This code indicates the presence of atypical squamous cells of undetermined significance (ASC-US) identified in a cytologic smear taken from the anus. ASC-US signifies cellular changes that are not clearly benign but do not meet the criteria for a high-grade lesion. It suggests a possible low-grade squamous intraepithelial lesion (LSIL) or human papillomavirus (HPV) infection.

Use this code when a pathology report for an anal cytology smear specifically states "Atypical Squamous Cells of Undetermined Significance (ASC-US)." This finding often prompts further investigation, such as repeat cytology, HPV testing, or anoscopy with biopsy. Documentation must clearly specify the anal origin of the smear.

• Do not use this code for ASC-US findings from other anatomical sites (e.g., cervix, vagina).
• This code represents a screening or diagnostic finding, not a definitive diagnosis of dysplasia or cancer.
• Sequence this code as the primary diagnosis when it is the reason for the encounter, such as for follow-up or further diagnostic workup.