Oth psychoactive substance dependence w persisting dementia

This code signifies a patient's physiological and psychological dependence on a psychoactive substance (excluding alcohol, opioids, cannabis, sedatives/hypnotics, cocaine, and other stimulants) that has resulted in a persistent, substance-induced dementia. The dementia is characterized by significant cognitive decline affecting memory, language, problem-solving, and other cognitive functions, directly attributable to the chronic substance use.

Use this code when documentation clearly indicates a diagnosis of dependence on a specified psychoactive substance (e.g., hallucinogens, inhalants, or other unspecified psychoactive substances) and a co-occurring, substance-induced dementia. The physician's notes should specify the causal link between the substance dependence and the persistent cognitive impairment.

• Always code the specific psychoactive substance if known (e.g., F16.27 for hallucinogen dependence). F19.27 is for "other" or unspecified psychoactive substances.
• Ensure the documentation explicitly states "dependence" and "persisting dementia" that is "substance-induced."
• Do not confuse with transient substance-induced cognitive disorders; this code is for persisting dementia.