Genetic anomalies of leukocytes

This code represents inherited or congenital abnormalities affecting the structure, function, or number of white blood cells. These anomalies are typically present from birth and are due to genetic mutations, leading to various leukocyte disorders that may or may not manifest with overt clinical symptoms.

Assign this code when documentation specifies a genetic or congenital defect of leukocytes, such as Pelger-Huët anomaly, May-Hegglin anomaly, or other inherited leukocyte morphology disorders. It is appropriate when the underlying genetic cause of the leukocyte abnormality is known or strongly suspected.

• Ensure documentation clearly states the genetic or congenital nature of the leukocyte anomaly to differentiate from acquired conditions.
• Do not use this code for Chédiak-Higashi syndrome, as it has a specific exclusion.
• Consider sequencing this code as a primary diagnosis if the leukocyte anomaly is the main reason for the encounter, or as a secondary diagnosis if it's an associated condition.