Acute megakaryoblastic leukemia not achieve remission

This code describes a rare and aggressive form of acute myeloid leukemia (AML) characterized by the uncontrolled proliferation of immature megakaryoblasts. It indicates that the patient's disease is currently active and has not responded to initial treatment or has relapsed, meaning a state of remission has not been achieved.

Apply this code when documentation explicitly states a diagnosis of acute megakaryoblastic leukemia and specifies that the patient is not in remission. This is typically used for initial diagnosis, during active treatment phases, or when monitoring a patient who has not achieved remission after therapy. Supporting documentation includes pathology reports confirming megakaryoblastic lineage and physician notes indicating active disease.

• Ensure documentation clearly states "not having achieved remission" or similar phrasing indicating active disease.
• Do not use this code if the patient is in remission (C94.21) or relapse (C94.22).
• Always sequence this code as the primary diagnosis when it is the reason for the encounter.