Diffuse follicle center lymphoma, spleen

This code identifies a specific type of non-Hodgkin lymphoma characterized by a diffuse growth pattern originating from follicle center cells, with primary involvement of the spleen. It represents a malignant neoplasm of lymphoid tissue.

This code is appropriate when diagnostic workup, including biopsy and imaging, confirms diffuse follicle center lymphoma with documented splenic involvement. It should be used for patients presenting with splenomegaly, B symptoms, or other signs of lymphoma where the spleen is identified as the primary or significant site of disease.

• Ensure documentation clearly specifies "diffuse" morphology and "follicle center" origin, along with splenic involvement.
• Do not confuse with follicular lymphoma (C82.0-C82.4) or other diffuse large B-cell lymphomas (C83.3-).
• Code any associated B symptoms (e.g., fever, weight loss, night sweats) separately if documented.