Disseminated histoplasmosis capsulati

This code signifies a severe, systemic fungal infection caused by Histoplasma capsulatum. It involves the spread of the fungus from the lungs to multiple organs throughout the body, often affecting the reticuloendothelial system. This disseminated form is particularly common in immunocompromised individuals.

Apply this code when documentation confirms a diagnosis of disseminated histoplasmosis due to Histoplasma capsulatum. This typically occurs in patients with widespread symptoms such as fever, weight loss, hepatosplenomegaly, lymphadenopathy, and bone marrow involvement, especially in endemic areas or in those with weakened immune systems. Lab confirmation (e.g., culture, antigen detection) or biopsy findings are usually present.

• Differentiate from localized pulmonary histoplasmosis (B39.0-B39.2) or other forms of histoplasmosis.
• Always look for documentation specifying "disseminated" or evidence of multi-organ involvement.
• Code any associated manifestations or complications, such as adrenal insufficiency or meningitis, as secondary diagnoses.