Intravenous leucovorin calcium administered in each 50 mg increment

This code represents the administration of leucovorin calcium, a folate analog often used as a rescue therapy or antidote. It is primarily given to counteract the toxic effects of folic acid antagonists, such as methotrexate, or to enhance the cytotoxic effects of fluorouracil in cancer treatment.

Use this code when leucovorin calcium is administered parenterally, typically via intravenous injection, for chemotherapy rescue or potentiation. Documentation should clearly specify the drug administered, the dosage in milligrams, and the route of administration.

• Report this code per 50 mg increments; if 100 mg is given, report two units.
• Do not confuse with oral leucovorin, which would be reported with an appropriate "J" code for oral chemotherapy if applicable, or not separately billable if incidental.
• Ensure the medical record supports the medical necessity for leucovorin administration, often in conjunction with chemotherapy drug codes.