Poisoning by fibrinolysis-affecting drugs

This code signifies an adverse reaction or overdose due to medications that influence the breakdown of fibrin, such as thrombolytics. It encompasses both accidental and intentional poisonings, as well as therapeutic misadventures involving these specific drug classes. The primary clinical manifestation is often related to bleeding or clotting abnormalities.

Use this code when documentation clearly indicates a patient has experienced poisoning from a fibrinolytic agent, including streptokinase, urokinase, or alteplase. This applies to situations where the drug was taken in excess, incorrectly administered, or caused an unexpected toxic effect. Supporting documentation should specify the drug involved and the nature of the poisoning.

• Always code an external cause of injury (E-code) in conjunction with this code to specify the circumstances of the poisoning (e.g., accidental, intentional, therapeutic misadventure).
• Distinguish poisoning from adverse effects of correctly administered drugs; poisoning implies an overdose or toxic reaction.
• Ensure the documentation specifies a fibrinolysis-affecting drug, as other anticoagulant or antiplatelet agents fall under different poisoning codes.