Poisoning by antineoplastic antibiotics

This code signifies an adverse reaction or overdose resulting from the ingestion, administration, or exposure to antineoplastic antibiotics. These are medications primarily used in chemotherapy to treat various cancers, and their toxic effects can manifest in multiple organ systems.

Assign this code when documentation clearly indicates a patient's signs and symptoms are directly attributable to poisoning by a chemotherapeutic agent classified as an antineoplastic antibiotic. This includes accidental overdose, intentional self-harm, or adverse effects from therapeutic use that reach a toxic level. Physician documentation must specify the drug class and the nature of the poisoning.

• Always code the specific manifestation(s) of the poisoning first, followed by this code as an E-code (external cause of injury and poisoning).
• Distinguish between adverse effects from proper therapeutic use (which would typically use an adverse effect code from the E930-E949 series) and true poisoning or overdose.
• Review medication lists and toxicology reports to confirm the specific drug involved and its classification as an antineoplastic antibiotic.