Monoclonal paraproteinemia

This code signifies the presence of an abnormal, single type of immunoglobulin (M-protein or paraprotein) in the blood, produced by a clone of plasma cells. It indicates a monoclonal gammopathy, which can be benign (MGUS) or associated with various lymphoproliferative disorders.

Apply this code when laboratory tests confirm the presence of a monoclonal protein in the serum or urine, and a more specific diagnosis like multiple myeloma or Waldenstrom's macroglobulinemia has not yet been established or ruled out. It is appropriate for cases of Monoclonal Gammopathy of Undetermined Significance (MGUS).

• Do not use this code if a definitive diagnosis of multiple myeloma (e.g., 203.00, 203.01) or Waldenstrom's macroglobulinemia (273.3) is documented.
• Consider sequencing this code as a secondary diagnosis if the primary reason for the encounter is a complication or symptom related to the paraproteinemia.
• Ensure documentation specifies the presence of a monoclonal protein, often identified through serum protein electrophoresis (SPEP) or immunofixation electrophoresis (IFE).