Cushing's syndrome

This code represents Cushing's syndrome, an endocrine disorder characterized by prolonged exposure of the body's tissues to high levels of cortisol. This can be caused by endogenous overproduction of cortisol (e.g., adrenal tumor, pituitary adenoma) or exogenous administration of glucocorticoids.

Use this code when documentation clearly indicates a diagnosis of Cushing's syndrome, regardless of its etiology. This applies to cases of pituitary-dependent Cushing's disease, adrenal tumors, ectopic ACTH production, or iatrogenic causes. Supporting documentation should specify the clinical findings consistent with hypercortisolism.

• Differentiate between Cushing's syndrome (hypercortisolism) and Addison's disease (adrenal insufficiency).
• If the cause of Cushing's syndrome is known (e.g., pituitary adenoma), code the underlying condition first, followed by this code.
• Avoid using this code for suspected or rule-out diagnoses; definitive clinical or laboratory evidence of hypercortisolism is required.