Malignant neoplasm of islets of langerhans

This code signifies a cancerous tumor originating from the endocrine cells (islets of Langerhans) within the pancreas. These tumors, often referred to as pancreatic neuroendocrine tumors (PNETs), can produce various hormones, leading to distinct clinical syndromes depending on the hormone secreted.

Apply this code when documentation explicitly states a malignant neoplasm of the islets of Langerhans or a malignant pancreatic neuroendocrine tumor. This diagnosis is typically confirmed through biopsy and histopathological examination.

• Differentiate from malignant neoplasms of the exocrine pancreas (e.g., adenocarcinoma), which are coded elsewhere.
• Specify the functional status (e.g., insulinoma, gastrinoma) if documented, using additional codes if available in the code set.
• Ensure the pathology report confirms malignancy and origin from the islets of Langerhans.