Adverse effect of macrolides, initial encounter

This code signifies an undesirable or harmful reaction to a macrolide antibiotic, occurring when the drug is administered correctly and at the appropriate dosage. It represents an unintended physiological response to the medication, distinct from an overdose or medication error.

Apply this code when a patient experiences an adverse drug reaction to a macrolide, such as gastrointestinal upset, QT prolongation, or allergic-like symptoms, during the initial phase of treatment. This is appropriate for reactions that are documented as an adverse effect rather than a poisoning or allergic reaction due to improper administration.

• Ensure documentation clearly states the reaction is an "adverse effect" of the macrolide, not an overdose or poisoning.
• Confirm this is the "initial encounter" for the adverse effect; subsequent encounters would use a different seventh character.
• Always code the specific manifestation of the adverse effect (e.g., nausea, arrhythmia) in addition to this code.