Generalized enlarged lymph nodes

This code signifies a widespread enlargement of lymph nodes throughout the body, not localized to a single region. It indicates a systemic lymphadenopathy, often a sign of an underlying infection, inflammatory process, or malignancy.

Apply this code when documentation clearly states "generalized lymphadenopathy" or describes enlarged lymph nodes in multiple, non-contiguous anatomical regions. This is a symptom code, and further investigation into the etiology is typically warranted.

• Do not use this code if the lymphadenopathy is localized to a specific region (e.g., cervical, inguinal); instead, use the appropriate R59.0x code.
• Always sequence this code after the definitive diagnosis if the cause of the generalized lymphadenopathy is known (e.g., infectious mononucleosis, lymphoma).
• If the underlying cause is unknown or still under investigation, this code may be a primary diagnosis.