Rh isoimmunization of newborn

This code signifies hemolytic disease of the newborn caused by Rh incompatibility between the mother and the fetus. Maternal antibodies, developed due to prior exposure to Rh-positive blood, cross the placenta and destroy fetal red blood cells, leading to anemia, hyperbilirubinemia, and potentially hydrops fetalis.

Use this code when a newborn is diagnosed with hemolytic disease specifically due to Rh isoimmunization. Documentation should clearly state the Rh incompatibility as the cause of the newborn's hemolytic anemia or jaundice, often confirmed by a positive direct Coombs test in the infant and a history of maternal Rh sensitization.

• Do not use this code for ABO incompatibility or other causes of hemolytic disease of the newborn; use more specific codes for those conditions.
• Ensure documentation specifies "Rh isoimmunization" to differentiate from other forms of isoimmunization.
• Code any associated conditions in the newborn, such as kernicterus or hydrops fetalis, in addition to this code.