Osteolysis, multiple sites

This code signifies the pathological destruction or dissolution of bone tissue occurring in multiple, distinct locations throughout the skeletal system. It indicates a generalized process of bone resorption rather than a localized lesion. This condition can lead to weakened bones, pain, and increased fracture risk.

Use this code when documentation clearly states "osteolysis, multiple sites" or describes widespread bone destruction affecting various anatomical regions. This is often seen in systemic conditions, metastatic disease, or certain metabolic disorders. Supporting documentation should specify the multi-site involvement, not just a single area of osteolysis.

• Ensure the documentation explicitly states "multiple sites" or lists several distinct affected bones to justify this code.
• Do not use this code for localized osteolysis; instead, refer to site-specific codes (e.g., M89.51-M89.58).
• Always code the underlying cause of the osteolysis first, if known (e.g., metastatic malignancy, metabolic bone disease).