Drug-induced systemic lupus erythematosus

This code signifies systemic lupus erythematosus (SLE) that is directly caused by the use of certain medications. It represents an autoimmune disorder characterized by inflammation and damage to various organ systems, specifically triggered by an exogenous drug.

Apply this code when documentation clearly states a diagnosis of drug-induced lupus erythematosus. This typically occurs when a patient develops SLE-like symptoms after initiating a new medication, and these symptoms resolve or improve upon discontinuation of the offending drug. Documentation should specify the drug implicated, if known.

• Always sequence this code first if it is the primary reason for the encounter.
• Do not use this code for idiopathic SLE; refer to codes in category M32.1-.
• Consider adding an external cause code (Y40-Y59) to identify the specific drug, if documented.