Insulin-like growth factor-1 (IGF-1) resistance

📋Clinical Description

This code describes a rare endocrine disorder characterized by the body's impaired response to insulin-like growth factor-1 (IGF-1), despite normal or elevated IGF-1 levels. This resistance can lead to growth failure, short stature, and other developmental abnormalities, as the tissues are unable to properly utilize IGF-1 for growth and metabolism.

🎯When to Use

Use this code for patients diagnosed with IGF-1 resistance, often presenting with severe short stature, microcephaly, and developmental delay. Documentation should clearly indicate a diagnosis of IGF-1 resistance, typically supported by genetic testing confirming mutations in the IGF-1 receptor or related pathways, alongside biochemical evidence of IGF-1 unresponsiveness.

💡Coding Tips

Differentiate from primary IGF-1 deficiency (E34.31) where IGF-1 levels are low.
Consider sequencing this code with other codes for associated clinical manifestations, such as short stature (R62.2) or intellectual disabilities (F70-F79).
Ensure the medical record explicitly states "IGF-1 resistance" or a similar definitive diagnosis.

AI-generated reference — verify against official guidelines

Clinical Notes

Inclusion Terms

Genetic syndrome with resistance to insulin-like growth factor-1
Insulin-like growth factor-1 receptor (IGF-1R) defect
Post-insulin-like growth factor-1 receptor signaling defect

Code Hierarchy

▲E34.32Genetic causes of short stature

E34.322(current)

Same Category

E34Other endocrine disorders E34.0Carcinoid syndrome E34.00Carcinoid syndrome, unspecified E34.01Carcinoid heart syndrome E34.09Other carcinoid syndrome E34.1Other hypersecretion of intestinal hormones E34.2