Primary insulin-like growth factor-1 (IGF-1) deficiency

This code represents a condition where the body does not produce enough insulin-like growth factor-1 (IGF-1) due to a primary defect, meaning the issue originates within the growth hormone (GH)-IGF-1 axis itself, rather than from a lack of growth hormone. This deficiency can lead to impaired growth and development, particularly in children, and various metabolic disturbances.

Use this code when documentation clearly indicates a diagnosis of primary IGF-1 deficiency, often confirmed by low serum IGF-1 levels despite normal or elevated growth hormone levels. This code is appropriate for patients with conditions like Laron syndrome or other genetic defects affecting IGF-1 synthesis or action.

• Differentiate from secondary IGF-1 deficiency, which is caused by growth hormone deficiency or other systemic conditions.
• Ensure documentation specifies "primary" IGF-1 deficiency to support this code.
• Consider co-reporting with codes for associated clinical manifestations, such as short stature (R62.52) or metabolic complications.