Primary adrenocortical insufficiency

This code represents a chronic endocrine disorder characterized by insufficient production of steroid hormones (cortisol and aldosterone) by the adrenal cortex. It results from damage to the adrenal glands themselves, leading to a deficiency in these essential hormones.

Use this code for patients diagnosed with primary adrenal insufficiency, often referred to as Addison's disease, where the adrenal glands are the primary site of pathology. Documentation should clearly indicate adrenal gland dysfunction as the cause of hormone deficiency, supported by laboratory findings of low cortisol and elevated ACTH.

• Differentiate from secondary adrenal insufficiency (E27.3), where the pituitary gland is the source of the problem.
• Review documentation carefully to exclude specific causes listed in the Excludes1 notes, such as tuberculous Addison's disease or adrenoleukodystrophy.
• Ensure the provider's documentation explicitly states "primary" adrenocortical insufficiency or "Addison's disease" to support this code.