Acute graft-versus-host disease

This code represents a severe, rapid-onset immune reaction where donor immune cells (graft) attack the recipient's (host) tissues following an allogeneic hematopoietic stem cell transplant. It typically manifests within the first 100 days post-transplant, affecting organs such as the skin, liver, and gastrointestinal tract.

Use this code when documentation clearly indicates a diagnosis of acute graft-versus-host disease (GVHD) in a patient who has undergone an allogeneic stem cell transplant. Supporting documentation should detail the onset, affected organs, and severity of the GVHD.

• Always sequence this code after the transplant complication code (e.g., T86.0- for bone marrow transplant complications).
• Do not confuse with chronic GVHD (D89.811), which has a later onset and different clinical presentation.
• Ensure the documentation specifies "acute" to differentiate from unspecified or chronic forms.