Severe combined immunodeficiency w low T- and B-cell numbers

This code represents a severe, inherited disorder of the immune system characterized by a profound deficiency in both T-lymphocytes and B-lymphocytes. Individuals with this condition are highly susceptible to recurrent, severe infections from birth, often leading to life-threatening complications if untreated. It is a primary immunodeficiency, meaning the defect is intrinsic to the immune system itself.

Use this code for patients diagnosed with severe combined immunodeficiency (SCID) where laboratory findings confirm significantly reduced numbers of both T-cells and B-cells. This diagnosis is typically made in infancy or early childhood based on clinical presentation of recurrent infections and specific immunological testing. Documentation should clearly state the diagnosis of SCID and specify the low T- and B-cell counts.

• Ensure documentation explicitly states "low T- and B-cell numbers" to support this specific subtype of SCID.
• Do not confuse with other SCID types that may involve normal B-cell counts or different genetic defects.
• Always sequence as the primary diagnosis when it is the reason for the encounter, especially for diagnostic workup or treatment of the underlying condition.