Leukocyte adhesion deficiency

Leukocyte adhesion deficiency (LAD) is a rare, inherited primary immunodeficiency characterized by recurrent bacterial infections, impaired wound healing, and often omphalitis due to defects in leukocyte adhesion and migration. This condition results from genetic mutations affecting proteins essential for neutrophils to adhere to endothelial cells and extravasate into tissues.

Assign this code for patients diagnosed with any type of leukocyte adhesion deficiency (e.g., LAD-I, LAD-II, LAD-III). Documentation should clearly indicate a confirmed diagnosis of LAD, typically supported by genetic testing, flow cytometry demonstrating absent or reduced adhesion molecules (e.g., CD18, CD15s), and a consistent clinical presentation.

• Differentiate from other primary immunodeficiencies; ensure documentation specifically states "leukocyte adhesion deficiency."
• Code any associated infections or complications (e.g., sepsis, osteomyelitis) separately and sequence appropriately.
• Review genetic testing results or immunology reports for definitive diagnosis and subtyping if available.