Osteomyelofibrosis

This code represents a chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, extramedullary hematopoiesis, and splenomegaly. It involves the abnormal proliferation of myeloid cells, leading to the replacement of normal bone marrow with fibrous tissue.

Use this code when documentation clearly indicates a diagnosis of osteomyelofibrosis, often identified through bone marrow biopsy showing significant fibrosis. This diagnosis is typically made after excluding other myeloproliferative disorders.

• Ensure documentation differentiates this chronic condition from acute myelofibrosis, which is coded elsewhere.
• Verify that the physician's diagnosis explicitly states "osteomyelofibrosis" or a synonymous term.
• Consider any associated symptoms or complications for additional coding, such as splenomegaly or anemia.