Multiple myeloma in relapse

This code signifies multiple myeloma that has recurred or progressed after a period of remission or stable disease. It indicates that the patient's plasma cell malignancy is actively manifesting again, requiring further treatment.

Apply this code when documentation explicitly states "multiple myeloma in relapse," "recurrent multiple myeloma," or "progressive multiple myeloma" following prior treatment. This is typically used for patients undergoing re-induction therapy or salvage regimens.

• Always confirm documentation specifies "in relapse" to differentiate from initial diagnosis or remission.
• Sequence this code first if it is the primary reason for the encounter.
• Do not confuse with multiple myeloma in remission (C90.01) or unspecified multiple myeloma (C90.00).