Heavy chain disease, in remission

This code signifies a malignant plasma cell dyscrasia characterized by the production of abnormal immunoglobulin heavy chains without associated light chains, which is currently in a state of remission. Heavy chain diseases are rare lymphoproliferative disorders affecting B-lymphocytes.

Apply this code when documentation explicitly states a diagnosis of heavy chain disease (e.g., Gamma, Alpha, or Mu heavy chain disease) and indicates that the disease is currently in remission. This typically follows successful treatment where there is no evidence of active disease.

• Ensure the documentation clearly specifies "in remission" for heavy chain disease, not just "resolved" or "history of."
• Do not confuse with other plasma cell dyscrasias like multiple myeloma or Waldenström macroglobulinemia, which have distinct ICD-10-CM codes.
• If the specific type of heavy chain disease (e.g., Gamma, Alpha, Mu) is documented, consider if a more specific code within the C88 category is available and appropriate.