Mantle cell lymphoma, lymph nodes of multiple sites

This code signifies a specific type of non-Hodgkin lymphoma, mantle cell lymphoma, affecting lymph nodes in more than one anatomical region. It represents a B-cell neoplasm characterized by the proliferation of small to medium-sized lymphocytes with irregular nuclei. This aggressive lymphoma often presents with widespread nodal involvement.

Apply this code when documentation confirms a diagnosis of mantle cell lymphoma with evidence of involvement in multiple lymph node sites, such as cervical, axillary, and inguinal nodes. This diagnosis is typically established through biopsy and immunohistochemical staining. Use this code for initial diagnosis, active treatment, or surveillance phases when multiple nodal sites are affected.

• Ensure the pathology report explicitly states "mantle cell lymphoma" and indicates involvement of more than one lymph node region.
• Do not use this code if the lymphoma is localized to a single lymph node region; instead, select the appropriate site-specific code.
• Consider additional codes for any associated symptoms, complications, or treatment modalities.