Mantle cell lymphoma, spleen

This code signifies a diagnosis of mantle cell lymphoma, a rare and aggressive type of non-Hodgkin lymphoma, specifically when the disease primarily involves or has metastasized to the spleen. It indicates the presence of malignant B-cells with characteristic cyclin D1 overexpression within the splenic tissue.

Use this code when documentation clearly states a diagnosis of mantle cell lymphoma with confirmed involvement of the spleen, either as the primary site or due to metastatic spread. This diagnosis is typically supported by pathology reports from splenic biopsies or splenectomy specimens, along with imaging studies showing splenic enlargement or lesions.

• Ensure documentation explicitly links mantle cell lymphoma to splenic involvement; do not assume splenic involvement from generalized lymphoma.
• Code any associated symptoms or complications of splenic involvement (e.g., splenomegaly, hypersplenism) as secondary diagnoses.
• Distinguish from other types of non-Hodgkin lymphomas affecting the spleen; pathology reports are crucial for accurate subtyping.